ZFIN Image: Lu et al., 2021, Fig. 4

Image

Figure Caption

Fig. 4 Functional verification of PI4KB for PKD. A The PKD phenotypes generated by PI4KB mutants. The asterisk indicates dilated tubules. B The statistical analysis for PKD phenotypes compared mutants with sibling controls. C The immunostaining of primary cilia for PI4KB mutant zebrafish. The white arrow represents the absence of single cilia in the pronephric duct of mutant zebrafish. D Western blotting and corresponding densitometry analysis demonstrate the expression level of PI4KB in the control vector and GNAS siRNA-transfected HK-2 cells. E, F Western blotting shows the activity change of t-Akt and p-Akt in the control vector, PI4KB siRNA, and GNAS siRNA-transfected HK-2 cells, respectively. The asterisk indicates p < 0.05. t-Akt, total Akt; p-Akt, phospho Akt.

Figure Data

Phenotype details

Acknowledgments

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