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Figure 7 Compound 8b inhibits migration and invasion of MDA-MB-231 cells (A). MDA-MB-231 cells were subjected to bicameral migration (blue) and invasion (purple) assay. Cells were treated with 5 μM of 8b and 10 μM of 9b for 24 h. Cells in the bottom of the 8 mm pore membrane were fixed and quantified. Microphotographs show crystal-violet-stained migratory and invasive cells (B). Magnification 40×, scale bar = 50 μm. Representative results from three independent experiments are shown. Significant difference between treatments was determined by t-test: ** p < 0.01.
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