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Figure 6 p66Shc hypomorphic allele improves MI outcome determinants in a ROS-dependent manner. (A) Representative stereomicroscopy images (top) and H&E stains (bottom) of resected hearts. (B) Quantification of zebrafish body mass effects, physical activity, and MI parameters from panel A. Hypomorphic allele zebrafish denoted as “HA”. **** = p-value < 0.0001, *** = p-value < 0.001, ** = p-value < 0.01, N = 7 independent fish for each measurement and presented as mean ± SD, N = 14 (weight ratio), N = 3 (injury and fibrotic area), N = 3 or 4 (ROS fluorescence), and N = 8 (physical activity).
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Full text @ J Cardiovasc Dev Dis