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Figure 3. OMS treatment induces M1-related proinflammatory responses in Mabc-infected mice in vivo.(a – d) qPCR analysis of Tnf, Il1b, Il12p40, and Ifng mRNA expression in C57BL/6 mice lung tissues. C57BL/6 mice were infected intranasally with Mabc (1 × 107 CFU), with or without OMS treatment (five times a week; 10 mg/kg i.p.), and monitored at 7 dpi (a – c) and 21 dpi (d). Statistical significance was assessed using one-way ANOVA with Tukey’s multiple comparison test (a – d). Data are means ± SEM of three independent experiments. * p < 0.05, *** p < 0.001. dpi, days post infection; OMS, ohmyungsamycin A; a.u., arbitrary unit; n.s., not significant. .