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Figure 1. Gene synteny around Nkx3.2 is well conserved in vertebrate genomes.
Phylogenetic tree of vertebrates based on commonly accepted topology. Pointed boxes represent gene orientation with gene names indicated on top. Red hexagons mark the position of conserved non-coding element (CNE) (jaw joint regulatory sequence 1, JRS1) downstream of Nkx3.2, where filled hexagons mark CNEs selected for in vivo functional characterization in this study. The corresponding chromosome/contig number of each locus is indicated below the gene order schematic of each species. Daggers indicate extinct species.
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