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Figure 4

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Publication: Crouzier et al., 2022 - NCS1 overexpression restored mitochondrial activity and behavioral alterations in a zebrafish model of Wolfram syndrome
All Figures: Figures for Crouzier et al., 2022

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Figure 4

Analysis of mitochondrial respiration in 5 dpf wfs1^KO zebrafish larvae

(A) Oxygen consumption rate (OCR) profiles of wfs1ab^WT and wfs1ab^KO zebrafish larvae at 5 dpf during the assay and calculated, (B) basal respiration rate, (C) ATP production-related OCR, (D) maximal respiration, (E) proton leak, and (F) non-mitochondrial respiration. Data are mean from triplicates and show mean ± SEM from n = 28 animals per genotype. Olig, oligomycin; FCCP, cyanide-p-trifluoromethoxyphenylhydrazone; Rot/AA, rotenone + antimycin A. ∗p < 0.05, ∗∗p < 0.01 versus wfs1ab^WT, unpaired t test.

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Acknowledgments

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