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Figure 5
Analysis of lymphocytic leukemia in zebrafish harboring SCID-derived JAK3 mutations. Histology of organs from afflicted zebrafish showing leukemic infiltration into the brain (A,B), liver (C,D), kidney (E,F) and intestine (G,H) in representative jak3 mutant fish at 12 months post fertilization imaged at 10× (A,C,E,G) and 40× (B,D,F,H) magnification. Yellow arrowheads indicate leukemic cell infiltration.
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