Figure 2

Figure 2

In vitro efficacy of CAH derivatives 3a–3l using therapeutic indices in SW10 cells treated with 1–100 µM of each compound for 10 h. (A) Dose–effect curve plot of 3a–3l indicated the cell viability of SW10 cells. (B) Cell growth curves of 3a–3l representing inhibition of cell proliferation were determined by the MTS assay in a dose-dependent manner. (C) Cell death was calculated as a ratio of live cells over dead cells via trypan blue exclusion assay. All CAH derivatives showed no in vitro efficacy in concentrations of ≤100 nM and 100% cell death in the concentration of 1 mM, respectively. CAH, cinnamaldehyde. CL, chalcone.