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Fig. 7
GlyR gating mechanism.
The ECD changes promote the transition from closed to the open state (A-C), while sustained binding of partial agonist promotes a further transition into the desensitized state (C-D).
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Reprinted from Cell, 184, Yu, J., Zhu, H., Lape, R., Greiner, T., Du, J., Lü, W., Sivilotti, L., Gouaux, E., Mechanism of gating and partial agonist action in the glycine receptor, 957-968.e21, Copyright (2021) with permission from Elsevier. Full text @ Cell