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Fig. 2
Figure 2. Molecular dynamics (MD) simulations used to test the stability of dihedral angle χCα–Cβ–Cγ–Cδ in various P2X structures. A–H, the fluctuation of dihedral angle χCα–Cβ–Cγ–Cδ during 0.5-μs MD simulations of zfP2X4 (A, resting; B, open), hP2X3 (C, resting; D, open), AmP2X (E, open), ckP2X7 (F, with bound inhibitor), and rP2X7 (G, resting; H, open). The trajectories were sampled every 200 ps. AmP2X, gulf coast tick (Amblyomma maculatum) P2X; ckP2X7, chicken (Gallus gallus domesticus) P2X7; hP2X3, human (Homo sapiens) P2X3; rP2X7, rat (Rattus norvegicus) P2X7; zfP2X4, zebrafish (Danio rerio) P2X4.
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Full text @ J. Biol. Chem.