ZFIN Image: Coffin et al., 2022, FIGURE 1

Image

Figure Caption

FIGURE 1

Some COVID-19 drugs are toxic to zebrafish hair cells. Hair cells were live-labeled with DAPI (blue), then fish were treated for 24 h in the indicated drug. The top left panel shows the vehicle controls with a full complement of hair cells. Methanol (MeOH) served as the vehicle for dexamethasone, while DMSO is the vehicle for all other drugs shown here. All other panels show representative confocal images for three concentrations of each drug. Left panels: non-ototoxic drugs dexamethasone, remdesivir, and azithromycin. Right panels: imatinib, lopinavir, ritonavir, and ivermectin all caused hair cell loss. Note that ivermectin was toxic to the animal at high concentrations, so only the non-lethal concentrations were used for this experiment. The scale bar in the upper left = 10 μm and applies to all panels.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Cell. Neurosci.