ZFIN Image: Ivica et al., 2022, Figure 1

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Figure Caption

Figure 1

AMS is a highly efficacious agonist on zebrafish ?1 GlyR.

(A) Structures of glycine, ?-alanine, AMS, and taurine. (B) Whole-cell current responses of HEK293 cells elicited by application of agonist solutions (pH 5) with a U-tube. Cells were held at ?40 mV. (C) Average concentration-response curves for glycine (black), ?-alanine (green), AMS (blue), and taurine (red), n=6?9 cells. Responses of AMS, ?-alanine, and taurine are normalized to those to a saturating concentration of glycine (100 mM) in each cell. AMS, aminomethanesulfonic acid.

Acknowledgments

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