Fig. 2

Fig. 2

Fig. 2. cluap1^hi3959a mutants have a 10 ​kb retroviral insertion in intron 1 of the cluap1 locus and display body axis symmetry defects. (A) Images of control and cluap1^{hi3959a/hi3959a} homozygous mutants at 4 dpf. Mutants display body curvature, a common phenotype of Danio rerio lines with mutant cilia proteins (Cao et al., 2010; Li and Sun, 2011; Sullivan-Brown et al., 2008). (B) Representation of the Danio rerio cluap1 locus. Cluap1 is oriented on the minus strand of chromosome 24 and has 12 exons. The 10 ​kb retroviral insertion that was used to make the cluap1^hi3959a line sits within intron 1, prior to the translation start site (Li and Sun, 2011).