Fig. 8

Fig. 8 Fig 8. Summary of study design and novel findings. Out of 59 Tier 1 and 2 human pharmacogenes, 45 were determined to have a zebrafish ortholog. The range of amino acid conservation between species was 44 – 83%. For pharmacogenes without published expression data, 3- and 5-dpf zebrafish were collected for gene expression analysis. Expression was demonstrated for 20 out of 26 previously unexplored pharmacogene orthologs. Gene ontology analysis of all 45 pharmacogene orthologs identified the top Biological Process, Molecular Function, and Cellular Component terms for future research, based on the number of highly conserved genes associated with each term.