ZFIN Image: Li et al., 2022, FIGURE 8

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FIGURE 8

Cratoxylumxanthone C inhibited proliferation and migration of A549 cells in zebrafish xenografts. CM-DiI stained A549 cells were microinjected into 2 dpf zebrafish embryos. After 4 h, tumor-bearing embryos were treated with cratoxylumxanthone C (2.5, 5, and 10 μM) and the positive control, etoposide (10 μM) for 48 h (n = 15/group). (A) Intensity and distribution of the red fluorescence were imaged under a confocal microscope of disseminated foci in zebrafish. (B) The proliferation was quantified by ImageJ software. (C) The metastasis of A549 cells were quantified using ImageJ software. All results are expressed as the mean ± SD. **p < 0.01 and ***p < 0.001 versus the control group.

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Acknowledgments

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