Figure 1

Figure 1

Morphology and survivability of APAP-treated larvae. (A–L) Lateral views of a single, representative larva either untreated (A,C,E,G,I,K) or continuously treated with 3.9-mM APAP from 2 hpf (B,D,F,H,J,L). Previously reported abnormalities visible here include reduced pigmentation, deformed tail and fin, failure to inflate swim bladder (compare (I) and (J)), peritoneal edema (arrowhead in (J)), and pericardial edema (arrowhead in (L)). Note the absence of a visible jaw or mouth in the APAP-treated larva (compare (K) and (L)). Many other larvae (not shown) also exhibit reduced body length and severe spinal curvature as reported elsewhere. Scale bar (in (L)) for (A–L), 1 mm. (M) Survivability of untreated larvae (n = 88) and larvae continuously treated with 3.9-mM APAP from 2 hpf (n = 98). The longest-lived treated larva survived until 11.5 dpf.