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Fig. 1
Zebrafish HCN4 channels are hyperpolarization-activated ion channels. (A) Representative currents of the human HCN4 channel HsHCN4 (black) and zebrafish HCN4 channels DrHCN4 (blue) and DrHCN4L (red). The holding potential was stepped from ?30 mV to ?130 mV in 10-mV decrements and held for 5 s at each potential. The inset shows the stimulation protocol. (B) Time constants obtained by fitting the activating currents of HsHCN4 (black), DrHCN4 (red) and DrHCN4L (blue) at ?130 mV. (C) Activation curves (G?V curves) of human and zebrafish HCN4 channels (n = 5 for each).
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Full text @ Front. Physiol.