ZFIN Image: Yang et al., 2022, Fig. 5

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Fig. 5

p.Gly224Val mutation leads to loss of function of EFTUD2 in the zebrafish model. p.Gly224Val mutation caused a loss of gene function of EFTUD2 during zebrafish embryogenesis. The EFTUD2 p.Gly224Val mutant mRNA decreased percentage of abnormality of embryonic neurodevelopment and cardiac development compared to EFTUD2 WT mRNA. Expression of pax2a and sox3 at 24 hpf, myl7 at 48 hpf, embryos at 24 hpf shown are lateral views with anterior to the left, embryos at 48 hpf shown are ventral view with the anterior at the top. Arrows point to the signal generated by detected marker genes. The percentage and numbers indicated in each image are the ratio for the number of affected embryos with phenotype similar to what is shown in the picture

Acknowledgments

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