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Fig. 4
Proposed binding for compound 8v (A) and 8s (B) in the colchicine site. In both 3-phenylpropylamino derivatives, the differently substituted phenyl rings in position 7 do not affect the potential occupation of the colchicine site and are placed as for compound 7ad. Co-crystallized colchicine is shown in light orange. The carbon atoms of the tubulin α subunit residues are shown in lilac, while the carbon atoms of the β subunit residues are represented in teal.
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