ZFIN Image: Cairelli et al., 2022, Fig. 5

Image

Figure Caption

Fig. 5

Fig 5. Effect of trapped fli1⁺/gata1⁺ cells on the endocardial WSS.

(A) Confocal image of a 3 dpf zebrafish embryonic heart that was crossed between the Tg(fli1a:Gal4ff;UAS:EGFP-CAAX) line and the Tg(gata1:DsRed) line. (B) Close up of the image showing several wobbling cells appear to be trapped within intra-trabecular spaces from the image. Some of these cells were fli1⁺ (blue arrows), while some were gata1⁺/fli1⁺ (red arrows). These were thus hypothesized to be developing hematopoietic cells. (C) Flow simulation WSS results with and without the hematopoietic cells at end-systole, demonstrating that the cells elevated endocardial WSS. (D) Average WSS magnitude (n = 2) from the simulations, calculated by averaging both spatially (over entire endocardial surface) and temporally (over entire cardiac cycle).

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Comput. Biol.