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Fig. 9
RNA-Seq analysis uncovers cell cycle genes as the key regulator of Dnmt1 inhibition during otic development of zebrafish. A, Volcanic plot analysis displays all the DEGs in the two groups. B, Venn map further labels the unique and overlapping number of DEGs in Con-MO and Dnmt1-MO groups. C, KEGG enrichment analysis exhibits the top 20 signalling pathways statistically different between Dnmt1 knockdown samples and the controls. D, Cluster analysis of DEGs on cell cycle pathway between the two groups. E, The ISH data confirm both cdkn1a (p21) and tp53 upregulated after knockdown of Dnmt1 compared to controls at 48 hpf
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