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Fig. 4
Downregulated Dnmt1 represses cell proliferation during primordium migration and neuromast formation. A-L, Representative images show the comparison in number of BrdU-labelled proliferating cells between controls embryos and Dnmt1-deficient mutants at 32 hpf in primordium (A-F) and at 48 hpf (G-L) in neuromasts. Scale bars mark the 10 μm scale. M-N, Significant differences in quantification of BrdU index in control embryos (n = 32) and Dnmt1-MO embryos (n = 31) were labelled. The arrowheads in B, E, H, K mark the proliferative cells. Dotted lines in A, C, D, F outline the primordium, and dotted lines in G, J, I, L outline the neuromast. Data are recorded as mean ± SEM. ****p < 0.0001
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