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Fig. 1
Dnmt1 is required for the development of zebrafish inner ear and pLL. The WISH staining delineates a persistent expression of Dnmt1 at two-cell stage (A), oblong stage (B), shield stage (C), segmentation period (D: lateral view, E: dorsal view, F: ventral view at 12 hpf and G: lateral view at 20 hpf). The high expression levels of Dnmt1 are concentrated on the migrating primordium (H and I), inner ear in the head region and deposited neuromasts in the posterior lateral line (J) from 26 to 48 hpf. The magnification-times images of primordium (I1), inner ear (J1) and neuromast (J2) structure indicate a strong expression of Dnmt1. The white bracket outlines sensory maculae HCs and white asterisks label semicircular canals (J1)
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