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Fig. 5 Figure 5. Cranberry pomace extract prevents virus entry by acting directly on ZIKV particles. (a) Schematic illustration of ZIKV inactivation assay performed to characterize the virucidal activity of the CP extract. ZIKVGFP was untreated (vehicle) or treated with the CP extract (100 µg/mL) for 2 h at 37 °C and subsequently diluted 50 times before infection of A549 cells. EGCG (100 µM) was used as a positive control. (b) Flow cytometric analysis under the experimental inactivation conditions shown in (a). The results are means ±SD of three independently performed experiments and are expressed as relative values to untreated infected cells. One-way ANOVA and Dunnett’s test were used for statistical analysis (**** p < 0.0001; n.s. = not significant).