ZFIN Image: Alhashem et al., 2022, Fig. 12

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Figure Caption

Fig. 12

Working model of trunk neural crest (TNC) migratory identity allocation through Notch-cell cycle interaction.

(A) Leader TNC progenitors divide asymmetrically giving rise to a prospective leader cell that is larger than the prospective followers that arise from symmetric divisions. (B) Interactions between TNC through Notch lateral inhibition establish higher levels of Notch activity in the bigger cell, triggering the initiation of S-phase and increased levels of phox2bb expression. (C) Leader cell initiated the chain movement while in S-phase trailed by followers in G₁. (D) Loss of the leader contact with premigratory TNC allows for a new round of Notch interaction that establishes a second leader cell.

Acknowledgments

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