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Figure 4

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Publication: Longhitano et al., 2022 - Lactate Induces the Expressions of MCT1 and HCAR1 to Promote Tumor Growth and Progression in Glioblastoma
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Figure 4

Lactate promoted the upregulation of mitochondrial activity gene expressions in glioblastoma cells. (A–F) Effect of lactate (20 mM) on mitochondrial biogenesis and OXPHOS gene expression in U-87 MG cells (A, B), A-172 cells (C, D), and U-251 MG cells (E, F) following 24 and 48 h of treatment. (G, H) Computerized analysis of the MitoTracker fluorescence intensity in the control versus lactate 18 h after treatment. The figures presented are representative of at least three independent experiments. Values represent the mean ± SEM of experiments performed in quadruplicate. P-values <0.05 were considered as statistically significant (*p < 0.05; **p < 0.01; ***p < 0.001 ; ****p < 0.0001 vs. untreated).

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