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Fig. 2
Figure 2. ∆ESX1-M. marinum does not induce OXSR1 gene expression.
(A) Relative expression of oxsr1a and stk39 in zebrafish embryos at 3 days post infection with ∆ESX1–M. marinum compared with age-matched uninfected controls. Biological replicates (n = 4) represent pooled RNA from 7 to 10 embryos. (B) Quantification of ∆ESX1–M. marinum bacterial burden in WT and mosaic F0 oxsr1a CRISPR embryos. (C) Quantification of ∆ESX1–M. marinum bacterial burden in WT, heterozygous and homozygous oxsr1a knockout embryos. (D) Quantification of ∆ESX1–M. marinum bacterial burden in DMSO vehicle control and Compound B–treated embryos at 1.8 μM.
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