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Fig. 5 PPAR modulation increases the incidence of aberrant islet morphologies at 4 dpf. Images were blinded prior to classification, and the incidence of ectopic β cells, fragmented islets, and hypomorphic islets (falling below the 10th percentile of controls) was recorded. For all PPAR isoforms, antagonism did not increase the incidence of aberrant islet morphologies (p > 0.05), while agonism increased incidence of aberrant islet morphologies (p < 0.05). Asterisks (*) above bars indicate a difference in total aberrant islet morphology between designated treatment group and the controls while asterisks within bars indicate a difference only in the associated morphology between designated treatment group and the controls (p < 0.05); n = 30–42 for each exposure group.