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Figure 5

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Publication: Maskin et al., 2022 - PPP6C, a serine-threonine phosphatase, regulates melanocyte differentiation and contributes to melanoma tumorigenesis through modulation of MITF activity
All Figures: Figures for Maskin et al., 2022

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Figure 5

The recurrent PPP6C(R264C) mutation confers a gain of function proliferation phenotype in melanoma. (A) Representative images of fish injected with either PPP6C(WT)-2A-NRAS(Q61K) or PPP6C(R264C)-2A-NRAS(Q61K) at 3- and 5-days post fertilization. (B) Quantification of proliferation as measured by the change in number of melanocytes from 72 to 120 h post fertilization, N = 15 fish (Student’s two-tailed t-test). (C) Representative melanoma-free survival curve comparing tumors expressing PPP6C(R264C) to PPP6C(WT). One of two independent experiments is shown (log-rank (mantel-cox) test). p-values are indicated as following: *p < 0.05, **p ≤ 0.01.

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