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Publication: Maskin et al., 2022 - PPP6C, a serine-threonine phosphatase, regulates melanocyte differentiation and contributes to melanoma tumorigenesis through modulation of MITF activity
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Figure 2

PPP6C disrupts melanocyte differentiation in vivo. (A) Representative images of 5 day old fish on the roy;nacre background injected with either MC-GFP, MC-PPP6C, or MC-PPP6C(R264C). (B) Representative counts of melanocytes of 5 day old fish on the roy;nacre background injected with either MC-GFP, MC-PPP6C, or MC-PPP6C(R264C) (Student’s two-tailed t-test). (C) Real-time qPCR measurement of SOX10 and MITF in 48 h post fertilization fish injected with either MC-GFP, MC-PPP6C or MC-PPP6C(R264C) (Student’s two-tailed t-test). (D) Real-time qPCR measurement of DCT, TYR, and TYRP1B in 48 h post fertilization fish injected with either MC-GFP, MC-PPP6C or MC-PPP6C(R264C) (Student’s two-tailed t-test). All data panels in the figure are representative of at least three experiments. p-values are indicated as following: *p < 0.05, ****p ≤ 0.0001.

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