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Publication: Maskin et al., 2022 - PPP6C, a serine-threonine phosphatase, regulates melanocyte differentiation and contributes to melanoma tumorigenesis through modulation of MITF activity
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Figure 1

PPP6C is recurrently mutated in melanoma and has a unique relationship to melanocyte lineage and MITF. (A) Lollipop plot showing the distribution of PPP6C mutations across the coding protein. The y-axis represents the number of mutations. Data represents PPP6C mutations found in 184 pan-cancer studies. 57/58 tumors containing a PPP6C(R264C) mutation were melanomas. (B) Dependency scores derived from CRISPR loss of function screens across multiple cancer and primary cell lines. A gene with a score of less than − 1 is considered essential in that cellular context. (C) Gene set enrichment analysis of the transcriptomes of 42 publicly available melanoma cell lines. Plot represents MITF target gene enrichment across increasing PPP6C expression.

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