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Figure 4 The main phase I metabolic pathway of 4F-MDMB-BINACA based on findings in the ZF larvae model (a) and from human screening (b). In panel (b), red arrows indicate results from human blood samples, and blue arrows indicate results from human urine samples. Metabolites in blue represent molecules not detected in the respective model. Four metabolites (M7, M8, M13, and M14) were not detected in the microinjected ZF larvae despite the detection of M3 and M10 as their following sequential metabolites. In contrast, terminal metabolites M1, M2, and M12 and a cross-connection between M3 and M4 were not found in human samples.