IMAGE

Fig 6

ID

ZDB-IMAGE-220227-30

Genes

EGFP
mCherry

Publication

Berger et al., 2022 - Genetic dissection of novel myopathy models reveals a role of CapZα and Leiomodin 3 during myofibril elongation

All Figures

Figures for Berger et al., 2022

Image

Figure Caption

Fig 6 Residual sarcomeres assemble within <italic toggle='yes'>capza1a</italic> and <italic toggle='yes'>capza1b</italic> depleted zebrafish.

(A) At 2 dpf, Lifeact-GFP (green) and mCherry-CaaX (red) highlighted the sarcomere organisation and myofibril striation within muscle fibres of WT siblings. In two out of four analysed capza1b^ex5 homozygotes, thin filament deposits (arrows) were detected at the peripheral ends of some fibres. Although myofibril striation (arrowheads) was detected in capza1b^ex5 homozygotes that were hetero- or homozygous for capza1a^ex5, thin filament deposits (arrows) were frequently located at the peripheral myofiber ends. (B) At 2 dpf, highly organised sarcomeres were found on transmission electron micrographs of siblings and capza1a^ex5;capza1b^ex5 compound homozygotes. However, electron-dense aggregates with a lattice structure (arrowheads) and filament deposits (star) were present close to the myosepta (arrow) in the compound homozygotes. Scale bar sizes are indicated.

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Genet.