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Fig. 7 Targeting SCs with ABT-263 reduces key pro-inflammatory and pro-fibrotic factors that are induced upon spinal cord injury (A–D) Cytokine and chemokine expression was measured in spinal cord homogenates from laminectomized (sham), vehicle-, and ABT-263-treated animals at 15 dpi. From a total of 111 factors analyzed, 26 were both upregulated upon injury (sham versus vehicle) and significantly decreased after ABT-263 treatment (vehicle versus ABT-263). Factors were divided in different groups regarding their role in (A) fibrosis, (B) inflammation, (C) cell adhesion, or (D) paracrine senescence. Some of the identified factors, displayed in bold, have been previously described as SASP factors. Data are expressed as mean density and presented as mean ± SEM. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, vehicle versus sham; #p < 0.05, ##p < 0.01, ###p < 0.001, ABT-263 versus vehicle.