ZFIN Image: Barthelson et al., 2021, Fig. 2.

Image

Figure Caption

Fig. 2. Microarray analysis of male 12-month-old homozygous App^NL-G-F mice. (A) Principal component analysis of brain transcriptome data from male 12-month-old homozygous App^NL-G-F (n=3), 3xTg (n=3), App wild-type (App^+/+, n=3) and non-transgenic (non-Tg, n=3) mice. The numbers in parentheses indicate the percentage of variation in the dataset explained by a principal component. Each point represents a sample, which are coloured by genotype. (B) Bar chart showing the FDR-adjusted P-value (directional hypothesis) from fry on marker genes of neurons, oligodendrocytes, astrocytes and microglia in App^NL-G-F relative to wild type. (C) Heatmaps indicating the expression (intensity) of genes within these marker gene sets summarised using K-means (K=4). (D) Heatmap showing the expression of genes in the KEGG_LYSOSOME gene set, clustered by their Euclidean distance. Each gene is labelled in red if they were identified as differentially expressed (DE), and the magnitude of the fold change (logFC) is shown in green.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.