ZFIN Image: Tatarakis et al., 2021, Figure 2.

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Figure Caption

Figure 2.

Temporal analysis of transcription factors in the NC

(A) NC dataset from Figure 1D re-analyzed using only TFs. The new UMAP shows the same broad structure but smoothens connections between time points (black lines).

(B) The same UMAP overlayed with pseudotime values calculated using Monocle3.

(C) Six modules of TFs identified with distinct expression profiles across pseudotime. Feature plots showing expression scores for each module overlayed with the UMAP. Three modules correspond to early NC, skeletal, and pigment branches, labeled as modules 1, 4, and 6, respectively (dashed line boxes), totaling 91 TFs.

(D) Heatmap showing correlation between TFs making up early NC, skeletal, and pigment modules. Hierarchical clustering reveals groups of co-expressed TFs. Selected representative genes are labeled along the side.

Acknowledgments

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