IMAGE

Figure 4.

ID
ZDB-IMAGE-220131-687
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Publication
Mei et al., 2022 - Disruption of PIKFYVE causes congenital cataract in human and zebrafish
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Figures for Mei et al., 2022
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Figure Caption

Figure 4.

Detailed characterization of cataract phenotypes in pikfyveΔ8 mutants.

(A) Confocal imaging of the lens of 5-dpf siblings and pikfyveΔ8 mutants in Tg(cryaa:DsRed) transgenic background. (B) Hematoxylin-eosin (HE) staining of 5-dpf siblings and pikfyveΔ8 mutant zebrafish lens after cryostat section. (C) ZL-1 antibody and DAPI staining of 5-dpf siblings and pikfyveΔ8 mutant zebrafish lens. (D) Transmission electron microscope (TEM) images of the lens of siblings and pikfyveΔ8 mutants at 3 dpf and 5 dpf. ASS, autophagy lysosome; LD, lipid droplet; N, nucleus. All results were confirmed in three different individuals. All the scale bars represent 10 μm.

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