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Figure 3
OP-B caused significant pyroptosis in A549/DDP cells. A. Transmission electron microscope images of tissue of tumor in situ (A549 and A549/DDP) after 3 mg/kg OP-B treatment for 14 days (Yellow triangles represent tumor cells). B-D. Mitochondrial membrane potential of A549 and A549/DDP cells was detected by flow cytometry after 5 μM OP-B treatment for 24 h. E-F. The level of LDH release in A549 (a) and A549/DDP (b) cells treated with different concentrations of OP-B after 6 h,12 h and 24 h.The bars and error bars indicate the mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.005, ****p < 0.001
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