ZFIN Image: Hwang et al., 2021, FIGURE 1

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Figure Caption

FIGURE 1 Structure and IC₅₀ of melatonin-like molecules. A, The molecular structures of melatonin (M) and its derivatives 1‒9. B, The effect of M and 1‒9 on cell viability in HCT116 human colon cancer cells. White bars indicate the cell viability when treated with compound at 1.0 mM. Values are expressed relative to vehicle-treated cells, normalized to 100% ± the standard deviation (SD), and were obtained from 3 independent experiments. *P <.05, **P <.01, and ***P <.001 in vehicle vs. compound treatment. The IC₅₀ values of M and 1‒9 in HCT116 human colon cancer cells were 4.48, 6.25, 5.60, 0.81, 0.56, 0.56, 8.51, 3.67, 2.87, and 0.41 mM, respectively

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Pineal Res.