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Figure 2
Screening of major cell death pathways via a DNA array approach with Bad knockdown at 24 hpf. (A) MA plot showing the distribution of upregulated and downregulated genes in the Bad MO group, with a cut-off of 2 fold changes compared to the Bad M5 group. The key factors p53 and caspase-8 are upregulated. The brain development genes crybb1, pva1b5, irx4a, pax7a, and fabp7a are marked in red. (B,C) Changes in biological function genes during loss-of-Bad-mediated PCD are analyzed in separate pie charts for upregulation (B) and downregulation (C).
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