Fig. 6

Fig. 6

Screen for active herbs, herbal combinations, and compounds of the XFBD recipe in macrophage mobilization. Quantification of the number of macrophages accumulated at the wounding site of embryos treated with (a) different XFBD herb extracts, (b) herb combinations, and (c) compounds. The dosages of each treatment are listed in the Sections 2.9 and 2.11. **: P < 0.01. Groups labeled without a common letter were significantly different (P < 0.05) in (b). (d) Molecular structure of compounds with significant effects in regulating macrophage recruitment. (e) Model of the regulatory effects of XFBD and its components on macrophage-mediated inflammation response. Red boxes highlight the active herbs identified from the macrophage activation model in P2P-stimulated RAW 264.7 cells; blue boxes highlight active herbs identified from the macrophage mobilization model in caudal fin-wounding zebrafish. CTR: tail-cutted embryos without treatment.