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Fig 6
Vaccination reduces augmented infection.
A-B Mice were vaccinated subcutaneously on day 0, 14 and 21 with vaccine (1 μg ClfA, 50 μg CpG and 1% w/v Alhydrogel, triangles) or PBS control (circles). Day 28 post-vaccination mice were intravenously injected with low dose S. aureus (1x106 CFU) high dose S. aureus (1x107 CFU), with both low dose S. aureus and 250 μg M. luteus PGN A diagram of experimental protocol B liver CFUs, enumerated 72 hpi (n = 10 per group, median value shown, two-tailed Mann-Whitney test), **p<0.002.
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