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Fig 8
Model showing that hyperactivation of PARP1 in response to ROS-induced DNA damage, and fueled by NAMPT-derived NAD+, mediates inflammation through parthanatos.
The inhibitors used are depicted in red. MIF, migration inhibitory factor; NAD+, nicotinamide adenine dinucleotide; NAM, nicotinamide; NAMPT, nicotinamide phosphoribosyltransferase; NMN, nicotinamide mononucleotide; NP, N-phenylmaleimide; Parp1, Poly(ADP-Ribose) polymerase 1; ROS, reactive oxygen species.
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