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Figure 7
miR-21 Promotes CAC development by activating PI3K/AKT, STAT3, and PDCD4/TNF-α (PSP) signaling networks. Representative images of miR-21-mediated gene regulatory network in CAC/CRC development. miR-21 can induce CRC or colitis-associated cancer (CAC) in ImiR-21 through another PI3K/AKT, PDCD4/TNF-α, and IL-6/STAT3 signaling network, leading to initial inflammation. miR-21 and TNF-α repress PDCD4 and its tumor-suppressive activity; eventually, active STAT3 stimulates a strong inflammatory response and activates the invasion/metastasis process of tumor cells.
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