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Figure 1
(A) Schematic drawing of the mature zebrafish retina showing the ciliary epithelium of the ciliary body (CE), the retinal pigment epithelium (RPE) and the neural retina with two differentiated regions: the CMZ, which contains different types of retinal progenitor cells (RPCs), and the central retina with a layered structure, which contains the outer (OPL) and inner (IPL) plexiform layers and three cell layers [ONL with the nuclei of cone (C) and rod (R) photoreceptors; inner nuclear layer (INL) with the nuclei of bipolar (B), amacrine (A), horizontal (H) and Müller glia (MG) cells; and a GCL with the nuclei of ganglion cells (G)]. (B). Timeline of the zebrafish life stages and ages analysed in this study. (C–F). Hemaetoxylin-eosin-stained transverse sections of the retina of 2 dpf (C), 4 dpf (D) and 1.5 mpf (E,F) zebrafish showing the maturation of retinal organization. Dashed lines in (D) and (E) indicate the limit between the CMZ and the central retina. (F) Detail of the central retina squared in (E). Scale bars: (C,D): 50 µm; (E): 200 µm; (F): 100 µm.