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FIGURE 2
Timeline illustrating the first identification of molecular defects in human EDS (above timeline) and the first description of engineered animal models targeting an EDS-associated gene (below timeline). Human genes associated with EDS without a corresponding animal model are indicated in dark gray. Note that for some human EDS subtypes, biochemical and/or ultrastructural findings preceded the identification of the molecular defect. Mouse models are depicted in light gray and zebrafish models in blue. Bold indicates what was first, either the identification of the human disease gene or the generation of the engineered animal model.