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Figure 6 KYNA/Ahr2 signaling defines the third distinct Alzheimer’s disease-responsive subset of neural stem cell population in adult zebrafish brain (A) Schematic view of the regulation of neural stem cell plasticity and neurogenesis in adult zebrafish brain by KYNA/Ahr2 signaling. (B) Consolidated view of the effects of Aβ42 on neural stem cell plasticity. Aβ42 reduces the expression levels of KAT2, which generates KYNA, an inhibitory regulator of neural stem cell proliferation through its receptor Ahr2. For successful regeneration to take place, tryptophan metabolism is suppressed and IL4/BDNF-mediated signaling mechanisms are enhanced.