ZFIN Image: Sullivan et al., 2021, Fig 8

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Figure Caption

Fig 8

A Mutant frequency to 10X MIC₉₀ EPT (0.63 μg/mL) or 10X MIC₉₀ EPT + 10X MIC₉₀ norvaline (590 μg/mL) in M. abscessus ATCC 19977 and M. tuberculosis H37Rv. Data shown is mean ± SD from biological triplicates. Means compared using Poisson distribution. *, p < 0.0001; ns, no statistical significance. B M. abscessus susceptibility to EPT with norvaline as an adjuvant. Data shown is mean ± SD from one experiment representative of three. C EPT in vivo activity in SCID mouse model of M. abscessus lung infection with norvaline supplementation. Rifabutin (RFB) acts as positive control. Data shown is mean ± SD of three to five mice per treatment group. Means compared using one-way ANOVA with Tukey’s multiple comparisons test. **, p < 0.007; ***, p < 0.0005; ****; p < 0.0001; ns, no statistical significance.

Acknowledgments

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