IMAGE

Fig. 7

ID: ZDB-IMAGE-210925-13
Publication: Shen et al., 2021 - The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling
All Figures: Figures for Shen et al., 2021

Image

Figure Caption

Fig. 7 CRBN modulates Wnt function in Drosophila.

a A schematic showing a Drosophila melanogaster wing imaginal disc. A anterior; P posterior; D dorsal; V ventral. b Representative confocal images showing the level of the Wg/Wnt biomarker Senseless (Sens, magenta) after RNAi-mediated knockdown of (i–iii) yellow (y) control or (iv–vi) ohgata (ohgt/crbn), driven by a hh-Gal4 driver in the posterior compartment of third instar wing imaginal disks. The region in which hh-Gal4 drives expression is indicated by Engrailed (En) in green. DAPI staining (blue) is used to mark the wing disc. hh hedgehog, dcr dicer. Scale bar = 50 μm. c A quantification of wing disks with a defect in Sens levels is shown. Asterisks indicate statistical significance (Fisher’s exact test, ****p value < 0.0001).

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat. Commun.