ZFIN Image: Zimmer et al., 2021, FIGURE 3

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FIGURE 3

SPI1/PU.1 expression in malformed cells occurs early in TSC development. SPI1 expression displayed a significant positive correlation with age in control samples (A). In contrast, TSC tuber tissue displayed a negative correlation with age samples (Pearson's correlation) (B). Fetal control cortex displayed sparse SPI1/PU.1 expression solely in few microglia (arrowheads in magnified lower panel) (C). Fetal TSC cases revealed strong expression of SPI1/PU.1 in malformed cells that could be found in subcortical clusters (arrowheads, magnified in lower panel) (D). SPI1/PU.1 expression was found to be variable between malformed cells (D₁). Sections C and D were counterstained with hematoxylin. Scale bars: 250 µm in upper panel and 50 µm in C (representative for D), 25 µm in D₁; A, B Spearman's rank correlation test (displayed with Spearman correlation coefficient ρ and exact p‐value)

Acknowledgments

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